By Michael B. M.D. Fossel
Far from in simple terms sharing a standard onset past due within the lifespan, age-related ailments are associated by means of basic universal features on the genetic and mobile degrees. Emphasizing human mobilephone mechanisms, the 1st part provides and analyzes our present knowledege of telomere biology and telephone senescence. In fabulous educational element, the textual content brings the reader brand new on telomere upkeep, telomerase dynamics, and present learn on cellphone senescence--and the overall model--cell senescence because the vital part in human senescence and melanoma. for every human malignancy, the bankruptcy stories and analyzes all to be had facts on telomeres and telomerase, in addition to summarizing present paintings on their medical program in either prognosis and melanoma therapy.
The moment variation, orientated through organs and tissues, explores the particular physiological effect of mobilephone senescence and getting older on medical disorder. After a precis of the literature on early getting older syndromes--the progerias--the textual content experiences getting older ailments (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune getting older, presbyopia, sarcopenia, etc.) within the context of the tissues during which they ensue. all the ten medical chapters--skin, cardiovascular process, bone and joints, hematopoetic and immune structures, endocrine, CNS, renal, muscle, GI, and eyes--examines what we all know in their pathology, the function of cellphone sensescence, and scientific interventions, either present and potential.
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Cells, Aging, and Human Disease by Michael B. M.D. Fossel